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Can 'Organs-on-a-Chip' Help Create Effective Drugs?

Can 'Organs-on-a-Chip' Help Create Effective Drugs?

The FDA seems to think so and is willing to spend $5.6 million to find out.

Earlier this month the regulatory agency invested in research being conducted by the Wyss Institute for Biologically Inspired Engineering at Harvard University. Specifically the research is to find out if the Organs-on-Chips technology the university developed can be used to test human physiological responses to radiation, and to evaluate drugs designed to counter those effects. The effort will also be supported by a team in the Vascular Biology Program at Boston Children's Hospital.

The larger application of this technology is the ability to test drugs on human organs as opposed to using animals for testing. This avoids not only the ethical issue of animal testing, but provides accurate responses as often animal models fail to predict human responses.

The Organs-on-Chips are tiny, microfluidic devices that are lined by living human cells and mimic complex organ physiology. Cells are either donated or are extra cells from surgical procedures.

The institute has over ten different organs-on-chips in development according to its Founding Director Don Ingber, M.D., Ph.D (To view a video of Dr. Ingber talking about this technology click here.)

This technology has been recognized internationally for its potential to replace animal testing and as a new way to model human disease, test new drugs, and screen for environmental toxins.

The Wyss Institute received support for its organs-on-chips technology from the Defense Advanced Research Projects Agency and the National Institutes of Health, which led to the development of these devices.


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