Two companies had more profit than sales (pretty hard to accomplish that feat), and several top financial performers found their way to this list. High sales totals are great, and big profits are nice, but profit margin has always been a great way to evaluate fiscal performance. By looking at profits as a portion of sales, you can find manufacturers in highly profitable niches
This is the last slideshow based on the 2022 IW U.S. 500 list of the country's largest manufacturing companies. Expect big changes when we unveil the 2023 list in the coming months.
| Rank | Primary Industry | Name | 2021 Revenue (in millions) | 2021 Profit Margin | 2021 Net Income (in millions) | 2021 Revenue Growth |
| 336 | Medical Equipment | Bio-Rad Laboratories Inc. | $2,923 | 145.28% | $4,246 | 14.8% |
| 335 | Medical Equipment | Cooper Companies Inc. | $2,923 | 100.76% | $2,945 | 20.2% |
| 95 | Pharmaceuticals | Regeneron Pharmaceuticals Inc. | $16,072 | 50.25% | $8,075 | 89.1% |
| 77 | Computers & Other Electronics | Texas Instruments Inc. | $18,344 | 42.35% | $7,769 | 26.9% |
| 439 | Pharmaceuticals | Quidel Corp. | $1,699 | 41.46% | $704 | 2.2% |
| 91 | Chemicals | DuPont de Nemours Inc. | $16,653 | 38.83% | $6,467 | 16.1% |
| 3 | Computers & Other Electronics | Microsoft Corp. | $168,088 | 36.45% | $61,271 | 17.5% |
| 55 | Computers & Other Electronics | Nvidia Corp. | $26,914 | 36.23% | $9,752 | 61.4% |
| 488 | Machinery | SPX Corp. | $1,220 | 34.88% | $425 | 8.1% |
| 212 | Instruments | Hologic Inc. | $5,632 | 33.23% | $1,872 | 49.1% |
Data provided by Seeking Alpha and S&P Global.
