Takata has been plunged into a public relations crisis as it faces lawsuits, calls for a criminal probe and accusations of "deception and obfuscation" over the deadly defect that has seen air bags deploy with excessive explosive power, spraying potentially fatal shrapnel into the vehicle.
One U.S. woman's death was initially investigated as a murder due to her grisly injuries until police switched their focus to the vehicle airbag.
On Friday U.S. regulators said they were fining Takata $14,000 a day, over claims it was stonewalling the investigation into the company's defective airbags.
In Tokyo, Honda shares slipped 0.91% to 3,928.5 yen with Ito's resignation announced after markets had closed.
Copyright Agence France-Presse, 2015